BMB4041071.5 ECTSQ2EnglishMaster
Chromosome Instability in Cancer
FaculteitFaculty of Medical Sciences
NiveauMaster
Studiejaar2026-2027
Beschrijving
Course goals
At the end of the course the student:
1. Understands basic molecular concepts of chromosome segregation in mitosis
2. Understands basic molecular concepts of DNA damage repair
3. Understands the impact of genome instability on cancer
4. Is familiar with the state-of-the-art in imaging and cell biology research
Content
Period: 1 February - 5 February 2027 (BMS_P2_A)
Faculty
Dr. Aniek Janssen
Dr. Gerben Vader
Invited guest speakers
Course description
This course will address the molecular basis for correct chromosome segregation during cell division, as well as the mechanisms that safeguard chromosome structure. Defects in these processes give rise to aneuploidy and structural chromosomal changes and many contribute to carcinogenesis.
Topics will include:
Faculty
Dr. Aniek Janssen
Dr. Gerben Vader
Invited guest speakers
Course description
This course will address the molecular basis for correct chromosome segregation during cell division, as well as the mechanisms that safeguard chromosome structure. Defects in these processes give rise to aneuploidy and structural chromosomal changes and many contribute to carcinogenesis.
Topics will include:
- Checkpoints that guard proper chromosome segregation and cell division
- Molecular organization and mechanical properties of the kinetochore
- Mitotic spindle assembly
- Cohesion of sister-chromatids
- Molecular regulation of double-strand break repair
- Chromosome mis-segregation, structural chromosomal changes and cancer
The course will consist of lectures and discussions by national and international experts in the field, combined with literature surveys, as well as work groups on the experimental aspects of mitosis research.
Literature/study material used
Research and review papers proposed by the guest lecturers
Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Students site.
Maximum capacity is 30. CSDB students have priority.
Mandatory for students in Master’s programme
N.A.
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge:
Bsc BMS / Biology
Maximum capacity is 30. CSDB students have priority.
Mandatory for students in Master’s programme
N.A.
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge:
Bsc BMS / Biology
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